The beauty and freedom of writing a stand alone is you can do anything you want. Blow up the world, go ahead. Have mutant alligators crawl out of the sewers…sweet. Your main character loses their mind midway in the book and runs around in his birthday suit shouting ‘I am the Master of the Universe,’ no problemo. Too, in this publishing environment as we’ve discussed, it seems it’s easier to sell a standalone. If you have a series, and that series hasn’t broken the house record in sales, then publishers are dang reluctant to take a chance on another book with those same characters. Whereas a one off is often seen as new and fresh and may get an editor excited at a house and want to champion your book.
–From a new interview with Gary Phillips